Michael Jackson

Michael Jackson picture]


















This post is about a true superstar character, a person who brought a lot of happiness, joy and amazement to our world, a really special person who from the earliest of ages shone with a special ability to awe people with his radiant brilliance, it is still a radiance that illuminates our world when ever his presence is apparent, and for many his presence is still greatly apparent. But, this is not an entertainment show business blog, of course I bring much knowledge of the showbusiness arena, because of my daliances, financial involvements, friends and admiration of what I consider to be one of the core binding substances of our race upon this planet, but, strictly speaking this entertainer is no ordinary planetary entertainer, this is the universe realm of... MICHAEL JACKSON...




Yes Michael, I laid on the floor for 40 days and forty nights, and could walk again after 3 months...


Michael Jackson / Billie Jean

http://www.youtube.com/watch?v=xwDkoJKPr4g&feature=related/


http://www.youtube.com/watch?v=3PAJqgeeJf4&feature=related/





atomic profiling picture]




Yes Michael, so did I...


Michael Jackson / Earth song

http://www.youtube.com/watch?v=K3vTBiOsSGY/



Beautiful, just beautiful...

The Jackson 5 / Can you feel it

http://www.youtube.com/watch?v=xW1fXL3s7bk&feature=related/




Michael jackson picture]



It is really interesting to look at human behaviour in pockets and regions, what baffled me was when newspaper owners printed stories that Michael Jackson was a madman for lying inside a rejuvination chamber that emmitted some sort of light, people said that it was to protect his skin colour and it's shade of colour. The really ironic thing is the number of people who actually laid on sunbeds for skin darkening, it's true to say that many people of light skin colour actually prefer and think brown skin more attractive, no one ever said that all those people were ''wacko sacko'', or figuratively speaking their boyfriends had chemicle reaction attraction improvements in the bed department. I personally tingle for milk white skin, has perhaps many other people do, but, it is certain to say that many many more very pale skin people lie on sunbeds for darker skin than people who do for lighter skin.

Verdict = Sacko wacko packo





Getting Off Tract: Polyglutamine Disease Involves Other Regions of Protein




(Sep. 23, 2010) — Many genes code for proteins that have a "polyglutamine tract," several glutamine amino acid residues in a row. Nine inherited neurodegenerative diseases, including Huntington's disease and spinocerebellar ataxia type 1 (SCA1), are associated with mutations that cause abnormally long polyglutamine tracts. One theory suggests that accumulation of proteins with extra glutamines damages and kills neurons. However, there is evidence that glutamine tract expansion alone is not sufficient to cause disease.


Now, new research published by Cell Press in the September 23 issue of the journal Neuron, reveals that initiation and progression of SCA1 are distinct from cell death and that changes outside of the polyglutamine tract are critical for disease pathogenesis. These findings could help to direct future therapeutic strategies for treating polyglutamine diseases.

SCA1 is thought to be caused by an expanded polyglutamine tract in an ataxin (ATXN1) protein that leads to damage and loss of Purkinje cells in the cerebellum. In addition, phosphorylation of a serine amino acid reside at position 776 (Ser776) is thought to be critical for pathogenesis. Recent research led by Dr. Harry T. Orr from the University of Minnesota showed that replacing Ser776 with a phospho-mimicking aspartic acid residue in ATXN1 with a normal polyglutamine tract seemed to elicit biochemical properties that resembled ATXN1 with an expanded polyglutamine tract.

To investigate the biological relevance of this earlier observation, Dr. Orr's group created transgenic mice that expressed different versions of ATXN1 in cerebellar Purkinje cells. "We found that a single amino acid change -- one that mimics phosphorylation at residue 776 -- converts wild type protein in a disease-causing protein. Clearly, phosphorylation is critical for this disease," explains Dr. Orr. The researchers went on to show that although the amino acid substitution caused the normal version of the protein to induce disease in cerebellar neurons, the pathogenesis did not progress to cell death.

Taken together, these results suggest that Ser776 is critical for initiating neuronal dysfunction, while an expanded polyglutamine tract is essential for neuronal death. "Obviously, the two are linked in that initiation is a prerequisite of later stages. Regardless, a treatment targeted at initiation, perhaps S776 phosphorylation, is likely to have a major impact clinically. Conversely treating just the cell death phase of the disease is unlikely to improve the neurological status of patients," concludes Dr. Orr.




So, sitting around during research for feild science really has been educational, but, I remember when this song arrived, for me, brown people had been kicking cultural ass for thousands of years, needless to say the segregational issues in North America didn't bother me, hey, I have been given an Indian name, silent fox, because I have an deep and sincere connection to life and respect the journeys that it gives man, for me, I am humbled, genuinely supremely thankful for the chance to breathe air and feel wind.


Michael Jackson picture]




For me, going into new territorial areas is about listening to the heavens and the people who live in them and the ancestors of the heaven regions. Michael Jackson was certainly an open intellectual for a true embracing life experience and, I myself personally have felt others who feel inhibited because they have yet to feel their true listening ears. Culturally wealthy is a Michael Jackson supremity that I wish to bestow upon the world, it is really one of the reseaons that Michael Jackson was a phenomenom in America, to me he is just a sincere human, a man, I have no worries or insufficiencies with being in company on the world with such people, I know it, he knows it, and the world knows, that to experience life and comprehend the gifts that god has for us, for some, it is a shedding process, that is evident with Michael Jackson's music.

Michael Jackson picture]



Michael Jackson picture]



Bathing in Michael Jackson warmth...





YYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYYIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII HHHHHHHHHHHHHHHHHHHHHHAAAAAAAAAAAAAAA!!!!!!!!!


Michael Jackson / Black or White

http://www.youtube.com/watch?v=mqZnxvAPkL8&ob=av2e/





Use of Sunless Tanning Products -- Common in Teens -- May Encourage Sun Safety in Women
(Sep. 25, 2010) — About one in ten U.S. adolescents uses sunless tanning products, and an intervention promoting these products as an alternative to regular tanning may reduce sunbathing and sunburns among adult women, according to two reports in the September issue of Archives of Dermatology, one of the JAMA/Archives journals.

Ultraviolet radiation exposure was recently upgraded to the highest cancer risk category and is the most common avoidable cause of skin cancer, according to background information in the articles. Sunless tanning products offer an alternative method of achieving tanned skin without exposure to UV rays from the sun or from indoor tanning beds. Most of these lotions and sprays contain dihydroxyacetone, a compound that combines with amino acids in the skin's outer layer to stain the skin a tanned color.
In one article, Vilma E. Cokkinides, Ph.D., of the American Cancer Society, Atlanta, and colleagues assessed the use of sunless tanning products among U.S. adolescents using a nationally representative telephone survey conducted between July and October 2004. A total of 1,600 adolescents age 11 to 18 provided information about whether they used these products in the past year, along with details about demographics, skin type, attitudes and perceptions of sunless tanning and other sun-related behaviors.
Of the teens surveyed, 10.8 percent reported using sunless tanning products in the past year. Those who used them tended to be older and female, to perceive a tanned appearance as desirable, to have a parent or caregiver who also used these products and to hold positive beliefs or attitudes about them. In addition, the use of sunless tanning products was associated with indoor tanning bed use and a higher frequency of sunburn.
"Our findings suggest that in adolescents, use of sunless tanning products appears independently correlated with risky UVR exposure behaviors (indoor tanning and having had sunburns in the previous summer) but not with routine use of sunscreen," the authors write. "Adolescents, therefore, must be educated about these products and the importance of avoiding indoor tanning and practicing sun-protective behaviors."
In another article, Sherry L. Pagoto, Ph.D., of the University of Massachusetts Medical School, Worcester, and colleagues recruited 250 women who were sunbathing at a beach to participate in a cancer prevention intervention study. Of these, 125 were assigned to receive information about skin cancer and sunless tanning. In a tent on the beach, trained research assistants provided the women written and verbal application instructions for sunless tanning products and information about the benefits of sunless tanning as compared with the risks of UV exposure. Participants had a UV-filtered photograph taken, which exposes skin damage not visible to the naked eye, and received free samples of sunscreen and sunless tanning products. The other 125, the control group, received free cosmetic samples not related to skin health and told they would be contacted for follow-up.
After two months, participants who had received the intervention reported sunbathing less frequently, having fewer sunburns, and using more protective clothing than those in the control group. After one year, the intervention group still sunbathed less and also used sunless tanning products more frequently than the control group.
"Encouraging sunbathers to switch to sunless tanning could have an important health impact, but sunless tanning has been considered a cosmetic more so than a health care tool," the authors write. "These findings have implications for public health and clinical efforts to prevent skin cancer. Promoting sunless tanning to sunbathers in the context of a skin cancer prevention public health message may be helpful in reducing sunbathing and sunburns and in promoting the use of protective clothing. Future research should determine how to further convince tanners to switch to sunless tanning."
Editorial: Assessing Patients' Tanning Motivations Can Help Guide Interventions
"Tanning for reasons of appearance, such as to look better or healthier, can be immediately satisfied with sunless tanning, but sunless tanning is a single hammer and there are many nails," write June K. Robinson, M.D., of Northwestern University Feinberg School of Medicine, Chicago, and editor of the Archives, and colleagues in an accompanying editorial.
"As physicians proffer sunless tanning as a substitute for intentional UVL-based tanning, it is important for them to know why and how often their patients tan. For example, an event tanner may believe that the expense of spray-on tanning is a good investment for a single event (e.g., the prom) whereas regular seasonal tanners, those who tan year-round, and those who often use tanning to improve their mood and relieve stress may be less likely to cease UVL exposure. Thus, these regular tanners may be more likely to simply add sunless tanning to existing UVL-based tanning habits."
"Because regular tanners appear to tan for reasons of appearance and mood, it is still possible that sunless tanning may help the regular tanner decrease the number of indoor tanning sessions in a month, thus achieving harm reduction when cessation of tanning is not feasible," they write. "Finding suitable stress-relieving and mood-enhancing alternatives to complement sunless tanning and substitute for UVL-based tanning would be important for these habitual tanners."






Neutron treatment for anti aging...



What Makes Us Age? Ticking of Cellular Clock Promotes Seismic Changes in Chromatin Landscape Associated With Aging


(Oct. 4, 2010) — Like cats, human cells have a finite number of lives: once they divide a certain number of times (thankfully, more than nine) they change shape, slow their pace, and eventually stop dividing -- a phenomenon called "cellular senescence."

Biologists know that a cellular clock composed of structures at the chromosome end known as telomeres records how many "lives" a cell has expended. Up to now, investigators have not yet defined how the clock's ticking signals the approach of cellular oblivion.
In a study published in the Oct. 3, 2010, issue of Nature Structural and Molecular Biology, a team led by Jan Karlseder, Ph.D., at the Salk Institute for Biological Studies reports that as cells count down to senescence and telomeres wear down, their DNA undergoes massive changes in the way it is packaged. These changes likely trigger what we call "aging."
"Prior to this study we knew that telomeres get shorter and shorter as a cell divides and that when they reach a critical length, cells stop dividing or die," said Karlseder, an associate professor in the Molecular and Cell Biology Laboratory. "Something must translate the local signal at chromosome ends into a huge signal felt throughout the nucleus. But there was a big gap in between."
Karlseder and postdoctoral fellow Roddy O'Sullivan, Ph.D., began to close the gap by comparing levels of proteins called histones in young cells-cells that had divided 30 times-with "late middle-aged" cells, which had divided 75 times and were on the downward slide to senescence, which occurs at 85 divisions. Histone proteins bind linear DNA strands and compress them into nuclear complexes, collectively referred to as chromatin.
Karlseder and O'Sullivan found that aging cells simply made less histone protein than do young cells. "We were surprised to find that histone levels decreased as cells aged," said O'Sullivan, the study's first author. "These proteins are required throughout the genome, and therefore any event that disrupts this production line affects the stability of the entire genome."
The team then undertook exhaustive "time-lapse" comparisons of histones in young versus aging cells and confirmed that marked differences in the abundance and variety of histones were evident at every step as cells moved through cell division.
O'Sullivan calls the "default" histone pattern displayed by young cells "happy, healthy chromatin." By contrast, he says, aging cells appear to undergo stress as they duplicate their chromosomes in preparation for cell division and have difficulty restoring a "healthy" chromatin pattern once division is complete.
Comparisons of histone patterns in cells taken from human subjects-a 9- versus a 92-year-old-dramatically mirrored histone trends seen in cell lines. "These key experiments suggest that what we observe in cultured cells in a laboratory setting actually occurs and is relevant to aging in a population," says Karlseder.
The initiation of diseases associated with aging, such as cancer, is largely attributed to DNA, or genetic, damage. But this study suggests that aging itself is infinitely complex: that progressive telomere shortening hastens chromosomal aging by changing the way genes entwine with histones, so-called "epigenetic" changes. How DNA interacts with histones has enormous impact on whether genes are expressed-hence the current intense interest in the relationship of the epigenomic landscape to disease states.
Rescue experiments in which the team cosmetically enhanced aging cells confirmed that signals emitted by eroding telomeres drove epigenetic changes. When aging cells were engineered to express telomerase, the enzyme that restores and extends stubby telomeres, those rejuvenated cells showed histone levels reminiscent of "happy, healthy chromatin," and a partial return to a youthful chromatin profile.
Lest you sink your savings into schemes to elongate your telomeres, beware. "The flip side of elongating telomeres is that you enable cells to grow for much longer periods and can generate what are called "immortal" cells," says Karlseder. "That takes you one step closer to cancer cell development."
Up to now, the Karlseder lab has mostly focused on interactions between telomeres and DNA repair mechanisms. This paper now pushes them into the field of epigenetics. "We will continue to examine epigenetic changes in cells at different ages," says Karlseder. "We now want to determine if histone changes follow a linear process or whether they kick in as we age."
Also contributing to this work were Stuart Schreiber, Ph.D., of the Broad Institute of Harvard and MIT and Howard Hughes Medical Institute and his postdoctoral fellow Stefan Kubicek, Ph.D.
The study was funded by the National Institutes of Health, the George E. Hewitt Foundation for Medical Research, and the Ernst Schering Research Foundation and the European Union.


Michael Jackson picture]






Michael Jackson picture]

Michael Jackson / The way you make me feel


http://www.youtube.com/watch?v=dPjfMSn4f6c&feature=related/


Astronaught techniques for walking on planets/moons/planetoids while conserving weight to energy ratio.





Stress Resilience Returns With Feeling for Rhythm




(Sep. 23, 2010) — If your body releases cortisol with fixed regularity then you can cope with stress better, says NWO-funded researcher Angela Sarabdjitsingh. She investigated the rhythm of corticosterone production in rats. This rat hormone is comparable to the human stress hormone cortisol. Rats deal considerably less well with stress if the pattern of corticosterone release changes. An irregular release pattern is a characteristic of chronic stress and stress-related diseases. It might therefore be possible to treat these by restoring the rhythm.


The hormone cortisol has to activate other proteins in the body and brain for a satisfactory response to stress. Yet Sarabdjitsingh discovered that important genes are activated less as soon as the rat's body is exposed to flattened corticosterone patterns. In a flattened pattern individual pulses are no longer recognisable as there are no more hourly peaks or troughs. That is interesting because conditions such as depression are characterised by a flattened rhythm in the cortisol release. Therefore it might be possible to treat such conditions by using medicines to adjust the rhythm.


Every hour the adrenal glands release the stress hormone cortisol (in rats corticosterone). However, disease or ageing can cause considerable disruption to this hourly rhythm with the result that the body responds less well to stress and pressure. Sarabdjitsingh investigated how the rhythm influences the stress response and the resilience of the hormonal and behavioural stress reaction. She also investigated if any changes in the pattern took place in tissues influenced by the stress hormone.


Crucial protein


Besides discovering that the rhythm of corticosterone release is crucial for a good hormonal and behavioural stress response, Sarabdjitsingh found out which protein predominantly suffers under a disrupted rhythm: the glucocorticoid receptor. This protein could therefore be an ideal target for the treatment of stress and stress-related diseases.


Mosaic


Angela Sarabdjitsingh obtained these results by being the first to combine a number of advanced techniques. These methods are now being used by other research groups as well to explore the subject further. Sarabdjitsingh carried out her unique research with a grant from the NWO Mosaic programme. Mosaic is a grant programme that funds the PhD research of students from ethnic minorities. Ethnic minorities are underrepresented within science and NWO, as a strong proponent of diversity, regrets the small number of role models. With Mosaic, NWO wants to prevent scientific talent from being unnecessarily lost.


Diffraction, dissatation astral water survey.

Michael Jackson dance tutorial / Indian walk

http://www.youtube.com/watch?v=b8HdHhf5LHo/




Michael Jackson / Rock with you

http://www.youtube.com/watch?v=cQ9GWsaxspA&ob=av3e/

Michael Jackson pictures]





Michael Jackson picture]




Prince Harry has the same birthday as me, I wonder if the reference to these historical songs serves as planetary science modules for kings and princes when learning their history, it's horrible when people confer and hidious rumour occurs, but, rumour is more than an echo, it is sad that such a beuatiful person like Princess Diana was involved with such a tragic epic saga, with the lesser known, but, ''dodi'' [12]. Traits traverse across countries and Princess Diana was certainly not afraid of being a persons people for the peoples person, and her work in our world was an exception among her womanhood, doing the dirty work as they say...


Michael Jackson / Dirty Diana

http://www.youtube.com/watch?v=bdjqcSCObuc/







Michael Jackson / Wanna be starting something

http://www.youtube.com/watch?v=ZP71oD_JcQg&feature=related/



[Chorus]
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)

[1st Verse]
I Took My Baby To The Doctor
With A Fever, But Nothing He Found
By The Time This Hit The Street
They Said She Had A Breakdown
Someone's Always Tryin' To Start My Baby Cryin'
Talkin', Squealin', Lyin'
Sayin' You Just Wanna Be Startin' Somethin'

[Chorus]
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)

[2nd Verse]
You Love To Pretend That You're Good
When You're Always Up To No Good
You Really Can't Make Him Hate Her
So Your Tongue Became A Razor
Someone's Always Tryin' To Keep My Baby Cryin'
Talkin', Screamin', Lyin'
You Got My Baby Cryin'

[Chorus]
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
You're A Vegetable, You're A Vegetable
Still They Hate You, You're A Vegetable
You're Just A Buffet, You're A Vegetable
They Eat Off Of You, You're A Vegetable

[3rd Verse]
Billie Jean Is Always Talkin'
When Nobody Else Is Talkin'
Tellin' Lies And Rubbin' Shoulders
So They Called Her Mouth A Motor
Someone's Always Tryin' To Start My Baby Cryin'
Talkin', Squealin', Spyin'
Sayin' You Just Wanna Be Startin' Somethin'

[Chorus]
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
You're A Vegetable, You're A Vegetable
Still They Hate You, You're A Vegetable
You're Just A Buffet, You're A Vegetable
They Eat Off Of You, You're A Vegetable

[Ad-Lib]
If You Cant Feed Your Baby (Yeah, Yeah)
Then Don't Have A Baby (Yeah, Yeah)
And Don't Think Maybe (Yeah, Yeah)
If You Can't Feed Your Baby (Yeah, Yeah)
You'll Be Always Tryin'
To Stop That Child From Cryin'
Hustlin', Stealin', Lyin'
Now Baby's Slowly Dyin'

[Chorus]
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
I Said You Wanna Be Startin' Somethin'
You Got To Be Startin' Somethin'
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)
It's Too High To Get Over (Yeah, Yeah)
Too Low To Get Under (Yeah, Yeah)
You're Stuck In The Middle (Yeah, Yeah)
And The Pain Is Thunder (Yeah, Yeah)

[Ad-Lib]
Lift Your Head Up High
And Scream Out To The World
I Know I Am Someone
And Let The Truth Unfurl
No One Can Hurt You Now
Because You Know What's True
Yes, I Believe In Me
So You Believe In You
Help Me Sing It, Ma Ma Se,
Ma Ma Sa, Ma Ma Coo Sa
Ma Ma Se, Ma Ma Sa,
Ma Ma Coo Sa






Michael Jackson / Blame it on the boogie

http://www.youtube.com/watch?v=amN8UynV5pA&feature=fvst/


Michael Jackson / Remember the time

http://www.youtube.com/watch?v=BMSDgNtBD8o&feature=related/






Stress Can Control Our Genes, Researchers Find


(Sep. 24, 2010) — Stress has become one of the major disease states in the developed world. But what is stress? It depends on from where you look.

You may experience stress as something that affects your entire body and mind, the causes of which are plentiful. But if we zoom in on the building bricks of the body, our cells, stress and its causes are defined somewhat differently. Stress can arise at the cellular level after exposure to pollution, tobacco smoke, bacterial toxins etc, where stressed cells have to react to survive and maintain their normal function. In worst case scenario, cellular stress can lead to development of disease.
Researchers from Dr. Klaus Hansen's group at BRIC, University of Copenhagen, have just shown that external factors can stress our cells through the control of our genes.
"We found that stress-activating factors can control our genes by turning on certain genes that were supposed to be silenced. It is very important that some genes are on and others are off in order to ensure normal foetal development and correct function of our cells later in life," says Hansen.
Simmi Gehani, PhD-student in the Hansen group, found that exposing human cells to a stress-activating compound turned on silenced genes. Even brief changes in gene activation can be disastrous during foetal development as establishment of correct cellular identity can be disturbed in our cells. But altered gene activity can also have consequences in the adult body. "For example, one could imagine that prolonged stress causes nerve cells in the brain to produce hormones and other signalling molecules they do not normally produce and this can disturb normal brain function," says Gehani.
The Hansen research group is very interested in understanding how our genes are turned on and off.
"We know that different protein complexes can associate with specific proteins (histones) to which DNA is wound around and thereby determine whether the genes are active or inactive. Small chemical groups can cause protein complexes to bind to histones and these can control gene activity" says Hansen.
The researchers have studied in detail a complex called PRC2. PRC2 can attach small chemical groups -- methyl groups -- to the histones. Protective complexes can bind to the histones when this marker is present and the genes are turned off.
Their new results show that the protective complexes are lost and selected genes turned on when cells are exposed to external stress factors. The reason why the complexes are lost is that the stress factors instruct an enzyme named MSK to attach another chemical group -- a phosphate group -- to the histones neighbouring the methyl group. The phosphate group neutralises the effect of the methyl group and turns specific genes on.
"The consequence is that genes that should be turned off are now active and this may disturb cellular development, identity and growth," says Gehani. This means that without damaging our genetic code external stress factors can control the activity of our genes.



stress factors signal to enzyme MSK picture]

Time lapse, superceding embrionics...

Michael Jackson / Moonwalk

http://www.youtube.com/watch?v=FQJPAsC9fcA&feature=related/


Michael Jackson moonwalker picture]



Michael Jackson moonwalker picture]




Michael Jackson / moonwalker


http://www.youtube.com/watch?v=kVaG5po34tM/

Michael Jackson pictures]

















You must learn to walk the walk, because the space business doesn't cater for people who just talk the talk...


Tell it... I would...


Michael Jackson / Smooth criminal


http://www.youtube.com/watch?v=zVh7FL7-SQw/


Michael Jackson picture]


Michael Jackson / You rock my world

http://www.youtube.com/watch?v=qJxCBoHMT7Q&feature=related/



Michael Jackson / Bad

http://www.youtube.com/watch?v=QnroWnC6seQ&feature=related/


Complexity Not So Costly After All: Moderately Complex Plants and Animals Can Be Better Equipped to Adapt


(Sep. 27, 2010) — The more complex a plant or animal, the more difficulty it should have adapting to changes in the environment. That's been a maxim of evolutionary theory since biologist Ronald Fisher put forth the idea in 1930.


But if that tenet is true, how do you explain all the well-adapted, complex organisms -- from orchids to bower birds to humans -- in this world?
This "cost of complexity" conundrum puzzles biologists and offers ammunition to proponents of intelligent design, who hold that such intricacy could arise only through the efforts of a divine designer, not through natural selection.
A new analysis by Jianzhi "George" Zhang and coworkers at the University of Michigan and Taiwan's National Health Research Institutes reveals flaws in the models from which the cost of complexity idea arose and shows that complexity can, indeed, develop through evolutionary processes. In fact, a moderate amount of complexity best equips organisms to adapt to environmental change, the research suggests. The findings will be published online in the Proceedings of the National Academy of Sciences.
The study focused on a genetic phenomenon called pleiotropy, in which a single gene affects more than one trait. Examples of pleiotropy are well known in certain human diseases, and the effect also has been documented in experimental animals such as fruit flies. Biologists also recognize its importance in development, aging and many evolutionary processes. However, pleiotropy is difficult to measure, and its general patterns are poorly understood, said Zhang, a professor of ecology and evolutionary biology.
Even so, scientists have developed mathematical models of the phenomenon, based on certain assumptions, and have made predictions from the results of the models. Zhang and coworkers decided to test the assumptions against real-life observations by analyzing several large databases that catalog the effects of specific genetic mutations on traits in model organisms (yeast, roundworms and mice). Each data set included hundreds to thousands of genes and tens to hundreds of traits.
For simplicity, mathematical models of pleiotropy have assumed that all genes in an organism affect all of its traits to some extent. But Zhang's group found that most genes affect only a small number of traits, while relatively few genes affect large numbers of traits.
What's more, they found a "modular" pattern of organization, with genes and traits grouped into sets. Genes in a particular set affect a particular group of traits, but not traits in other groups.
In addition, the researchers learned that the more traits a gene affects, the stronger its effect on each trait.
All of these findings challenge the assumptions underlying the classic mathematical models that suggest complexity is prohibitively costly.
When Fisher first wrote about the cost of complexity, he argued that random mutations -- which, along with natural selection, drive evolution -- are more likely to benefit simple organisms than complex organisms.
"Think of a hammer and a microscope," Zhang said. "One is complex, one is simple. If you change the length of an arbitrary component of the system by an inch, for example, you're more likely to break the microscope than the hammer."
In a paper published in 2000, evolutionary geneticist H. Allen Orr of Rochester came up with additional reasons for the cost of complexity. According to his model, even if a mutation benefits a complex organism, it's unlikely to spread throughout the whole population and become "fixed." And even if it does that, the advantage of the mutation is likely to be small.
By incorporating a more realistic representation of pleiotropy, Zhang's analysis found the reverse of Orr's arguments to be true. Although Fisher's observation still holds, reversing Orr's assertions minimizes its impact, thus reducing the cost of complexity.
Further, the analysis showed that the ability of organisms to adapt is highest at intermediate levels of complexity. "This means a simple organism is not best, and a very complex organism is not best; some intermediate level of complexity is best in terms of the adaptation rate," Zhang said.
The new findings help buffer evolutionary biology against the criticisms of intelligent design proponents, Zhang said. "The evolution of complexity is one thing that they often target. Admittedly, there were some theoretical difficulties in explaining the evolution of complexity because of the notion of the cost of complexity, but with our findings these difficulties are now removed."
Zhang's coauthors on the paper are former U-M graduate student Zhi Wang, now at Sage Bionetworks in Seattle, Wash., and Ben-Yang Liao of the National Health Research Institutes in Taiwan.
Funding was provided by the U.S. National Institutes of Health and the Taiwan National Health Research Institutes.



Perhaps the development of particular ways of moving around on particular landing regions of asteroids, moons, and planetoids could be developed for the effects of slowing weighless reaction and biological motor neuron reaction to pressure, of course, I not suggesting we learn to walk completly differently and evolve into another species, but, it gives us a wide array of data to study, particularly microbiology and a therie I have myself about how planetary orbits would time the fruition of life that could exist in hybernation stages much more dependant on longer astrological path alignments, similarly speaking, It could become more appropriate to traqvel into deep space at different times of the year according to time of month and most noteably as I have been testing in astronaught training circadian rhythm. Mr President Barack Obama would be most pleased to report to the muslim world our study and knowledge of why The prophet mohamed urges all muslims to pray 5 times a day facing the sun, from dawn until dusk to lower ion build up in their plasma levels.

a picture of a crab

http://www.youtube.com/watch?v=ZTeKOYu2nok&feature=related

http://www.youtube.com/watch?v=iuc1nso8WyE



http://www.youtube.com/watch?v=upUAiJyqSH0&feature=related

Examining film monitering looking for forward motion could actually be an interesting ''breakthrough'' in the search for life in other environments when the search is expanded to different motion sequences such as as avionic class atmospheric movement, i.e barometric moving patterns designed for stealth pressure [e=mc squared mass bending camaflage] maneuvers, wind and water interaction designed for light motion mimicking which would actually see all vapour and light trails folded into an under current dimension thus hiden from all radar signitures, and obviously ion trails hidden by an extended period of moving into a particular flight path, walk path, motion sequence path, [muslims praying for ion releif=aries].


Michael Jackson at the White house 1984 picture]


Traveling through deep space will obviously prove many many different regions of plasma offer dangerous plasma diseases that our body will need to evolve through if we ever colonise those regions, the start of that process will require a lot of scientific research, for astronaughts travelling into regions that have density differences to their natural or chosen habitat, barionic chambers will certainly be a damage limitation resource availability, Michael Jackson's evolution on our planet was and is a very public spectacle, but, in every way a serious lesson has been learnt by those who respect life in it's differences and complexities that sometimes we just do not know the inner workings of characters and how quickly they evolve in the fabric of space time.

Much like the Muslim world's desicion to dodge the ion fallout from neuclides coming from outer space by lowering their centre of gravity at specific times of the day, Michael Jacksons need to align with his inner feelings show us that his sensitivity to atmospherics was way more advanced than his generations sensitivity to regionics.

Michael Jackson barionic chamber pictures]






Michael Jackson / Rocking Robin

http://www.youtube.com/watch?v=azpntxKAe0E&feature=related

http://www.youtube.com/watch?v=u2vzTKh-O5c&feature=related

http://www.youtube.com/watch?v=C4VCUbL7jsc&feature=related


Michael Jackson picture]
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Playing White Noise in Class Can Help Inattentive Children Learn, but Hinder Others




(Sep. 29, 2010) — Playing white noise in class can help inattentive children learn. Researchers writing in BioMed Central's open access journal Behavioral and Brain Functions tested the effect of the meaningless random noise on a group of 51 schoolchildren, finding that although it hindered the ability of those who normally pay attention, it improved the memory of those that had difficulties in paying attention.

Göran Söderlund from Stockholm University, Sweden, worked with a team of researchers to carry out the experiments at a secondary school in Norway. He said, "There was significant improvement in performance for the children rated as inattentive by their teachers, and a significant decline in performance for those rated as attentive as noise levels were increased. This finding could have practical applications offering non-invasive and non-pharmacological help to improve school results in children with attentional problems."
The children were challenged to remember as many items as possible from a list read out either in the presence or absence of white noise. The researchers speculate that a phenomenon called 'stochastic resonance' may explain the improved performance of inattentive pupils seen in the test. According to Söderlund, "When a weak signal is presented below the hearing threshold it becomes detectable when random or white noise is added to the signal. Our study is the first to link noise and stochastic resonance to both higher cognitive functions and attention."




Michael Jackson / Pyt

http://www.youtube.com/watch?v=7gZzt6UeqHQ&feature=related/



yes, during life we have three commom stages child, teenager, adult, it's simple, you must learn how to get from a to b...

Michael Jackson picture]




The Jackson 5 / ABC

http://www.youtube.com/watch?v=i9hQIrsHaS4&feature=related/



For Neurons to Work as a Team, It Helps to Have a Beat




(Sep. 28, 2010) — When it comes to conducting complex tasks, it turns out that the brain needs rhythm, according to researchers at the University of California, Berkeley.

Specifically, cortical rhythms, or oscillations, can effectively rally groups of neurons in widely dispersed regions of the brain to engage in coordinated activity, much like a conductor will summon up various sections of an orchestra in a symphony.
Even the simple act of catching a ball necessitates an impressive coordination of multiple groups of neurons to perceive the object, judge its speed and trajectory, decide when it's time to catch it and then direct the muscles in the body to grasp it before it whizzes by or drops to the ground.
Until now, neuroscientists had not fully understood how these neuron groups in widely dispersed regions of the brain first get linked together so they can work in concert for such complex tasks.
The UC Berkeley findings are being published in the online early edition of the journal Proceedings of the National Academy of Sciences.
"One of the key problems in neuroscience right now is how you go from billions of diverse and independent neurons, on the one hand, to a unified brain able to act and survive in a complex world, on the other," said principal investigator Jose Carmena, UC Berkeley assistant professor at the Department of Electrical Engineering and Computer Sciences, the Program in Cognitive Science, and the Helen Wills Neuroscience Institute. "Evidence from this study supports the idea that neuronal oscillations are a critical mechanism for organizing the activity of individual neurons into larger functional groups."
The idea behind anatomically dispersed but functionally related groups of neurons is credited to neuroscientist Donald Hebb, who put forward the concept in his 1949 book "The Organization of Behavior."
"Hebb basically said that single neurons weren't the most important unit of brain operation, and that it's really the cell assembly that matters," said study lead author Ryan Canolty, a UC Berkeley postdoctoral fellow in the Carmena lab.
It took decades after Hebb's book for scientists to start unraveling how groups of neurons dynamically assemble. Not only do neuron groups need to work together for the task of perception -- such as following the course of a baseball as it makes its way through the air -- but they then need to join forces with groups of neurons in other parts of the brain, such as in regions responsible for cognition and body control.
At UC Berkeley, neuroscientists examined existing data recorded over the past four years from four macaque monkeys. Half of the subjects were engaged in brain-machine interface tasks, and the other half were participating in working memory tasks. The researchers looked at how the timing of electrical spikes -- or action potentials -- emitted by nerve cells was related to rhythms occurring in multiple areas across the brain.
Among the squiggly lines, patterns emerged that give literal meaning to the phrase "tuned in." The timing of when individual neurons spiked was synchronized with brain rhythms occurring in distinct frequency bands in other regions of the brain. For example, the high-beta band -- 25 to 40 hertz (cycles per second) -- was especially important for brain areas involved in motor control and planning.
"Many neurons are thought to respond to a receptive field, so that if I look at one motor neuron as I move my hand to the left, I'll see it fire more often, but if I move my hand to the right, the neuron fires less often," said Carmena. "What we've shown here is that, in addition to these traditional 'external' receptive fields, many neurons also respond to 'internal' receptive fields. Those internal fields focus on large-scale patterns of synchronization involving distinct cortical areas within a larger functional network."
The researchers expressed surprise that this spike dependence was not restricted to the neuron's local environment. It turns out that this local-to-global connection is vital for organizing spatially distributed neuronal groups.
"If neurons only cared about what was happening in their local environment, then it would be difficult to get neurons to work together if they happened to be in different cortical areas," said Canolty. "But when multiple neurons spread all over the brain are tuned in to a specific pattern of electrical activity at a specific frequency, then whenever that global activity pattern occurs, those neurons can act as a coordinated assembly."
The researchers pointed out that this mechanism of cell assembly formation via oscillatory phase coupling is selective. Two neurons that are sensitive to different frequencies or to different spatial coupling patterns will exhibit independent activity, no matter how close they are spatially, and will not be part of the same assembly. Conversely, two neurons that prefer a similar pattern of coupling will exhibit similar spiking activity over time, even if they are widely separated or in different brain areas.
"It is like the radio communication between emergency first responders at an earthquake," Canolty said. "You have many people spread out over a large area, and the police need to be able to talk to each other on the radio to coordinate their action without interfering with the firefighters, and the firefighters need to be able to communicate without disrupting the EMTs. So each group tunes into and uses a different radio frequency, providing each group with an independent channel of communication despite the fact that they are spatially spread out and overlapping."
The authors noted that this local-to-global relationship in brain activity may prove useful for improving the performance of brain-machine interfaces, or lead to novel strategies for regulating dysfunctional brain networks through electrical stimulation. Treatment of movement disorders through deep brain stimulation, for example, usually targets a single area. This study suggests that gentler rhythmic stimulation in several areas at once may also prove effective, the authors said.
Other co-authors of the study are Jonathan Wallis, UC Berkeley associate professor of psychology; Dr. Karunesh Ganguly, UC Berkeley post-doctoral fellow in the Carmena lab and staff scientist at the San Francisco Veterans Affairs Medical Center; Steven Kennerley, now a senior lecturer at University College London's Institute of Neurology; Charles Cadieu, UC Berkeley post-doctoral researcher in neuroscience; and Kilian Koepsell, UC Berkeley assistant researcher in neuroscience.
The National Institutes of Health, National Science Foundation, U.S. Department of Veterans Affairs, American Heart Association, Defense Advanced Research Projects Agency and the Multiscale System Center helped support this research.




Michael Jackson / Beat it

http://www.youtube.com/watch?v=p3jCPtxOkGo&ob=av2e/


Evolving research methods only have one path, it is why we name them pathogens for medical term intercranial action.




Suppose I should get back to work...



Michael Jackson / Don't stop til you get enough

http://www.youtube.com/watch?v=08_Jsfi1dbE&feature=channel/







Marilyn Monroe picture]